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PPA Application Guidelines

Application Procedures for New, Renewal and Revised Proposals

To facilitate the preparation of future NIH-AREA (R15) and/or NIH SuRE (R16) proposals, applicants must follow the instructions and format of one of these funding mechanisms.


Since there are two R16-SuRE award programs and multiple R15-AREA Funding Opportunity Announcements (FOAs) with different eligibility criteria, applicants must use the appropriate R15 or R16 FOA number for the Institute/Program that matches their research objectives/plan. 


For R16 FOAs: see SuRE-First for investigators without prior externally funded grant support, and SuRE for investigators previously, but not currently, receiving NIH research grant support. (Note: R16 award mechanisms do not support research involving clinical trials)


For R15 FOAs: see the NIH Guide to Grants and Contracts-R15:


The application instructions must be carefully adhered to, except where they have been modified by the following Supplemental Instructions. Applications not following the guidelines will be returned without review.


I. New applications from first time applicants should follow the instructions below.

II. Applications from previously KY INBRE funded investigators should essentially be revised applications of the PIs previously submitted NIH R15 or R16 proposal, and should follow NIH guidelines for resubmissions, including a one-page introduction that addresses the NIH reviewers concerns and criticisms A copy of the NIH R15/R16 review must be submitted with the proposal.

III. Applications from prior NIH R15/R16 funded investigators: For bridge funding requests, the application should be the PIs competitive R15/R16 renewal application with a one year budget and a one-page introduction providing R15/R16 renewal status and plans, along with a justification for continued support. If preparing a revision of the competitive renewal application, then the most recent NIH reviews must be attached.

IV. Applications from previously not funded PPA applicants:

a. Resubmission of revised PPA proposals should follow the NIH guidelines for resubmissions and include a one-page introduction that addresses the previous KY INBRE reviewers concerns and criticisms and indicates how the proposal has been revised.

b. Completely new proposals from previously not funded applicants should include a one-page introduction that briefly explains how the new proposal differs from the previously submitted application. The introduction should also indicate how the new proposal addresses any of the KY INBRE review committee’s generic concerns/criticisms (e.g., lack of publications, student involvement, facilities or resources, etc.) of the previously submitted proposal. If there is any overlap between the new and previously submitted proposal, then the introduction should address all previous concerns/criticism that may be relevant to the new proposal.


If you need any clarification, please contact your institutional “Lead” faculty member, the KY INBRE Program Director/PI (Dr. Martha Bickford) or Program Coordinator (Dr. Bruce Mattingly) prior to submission of your proposal.


The KY INBRE Data Science Core provides additional research and training support in Bioinformatics, Genomics, Electron Microscopy, and Applied Statistics. Researchers are encouraged to contact these facilities for assistance in developing research proposals (KY INBRE, NIH) as well as for technical assistance in conducting the research and/or preparing manuscripts for publications.


For additional assistance with R16 proposals, the SuRE Resource Center is also available for advice and consultation. 

Supplemental Instructions

Applications should be prepared using NIH ASSIST or Grants.gov Workspace. Once completed, a PDF copy of the entire application should be saved and submitted to the KY INBRE.


In addition to the completed application package, you must complete and submit the following PHS 398 forms signed by the authorized institutional official:


Form Page 1: Face Page

Form Page 2: Summary, Relevance, Project/Performance Sites, Senior Key Personnel, etc.


These forms may be found at: https://grants.nih.gov/grants/funding/phs398/phs398.html


Complete all mandatory forms and attachments in the R15 or R16 application package.


Complete all mandatory forms and attachments in the R15 or R16 application package.



A detailed budget justification is required for both R15 & R16 proposals.

Maximum award is $50,000 direct costs for one-year with a start date of May 1 and end date of April 30th. Requests for funding may include expenses for supplies, equipment, use of core facilities, travel (max. $2500), summer salary, and undergraduate research assistants. Funds (up to $6,000 annually of the $50,000 max) may also be requested to partially cover the cost of faculty release time. Grant funds may not be used to directly pay the salary of another individual for course release time. Funds (up to $6,000 annually of the $50,000 max) may be requested to partially cover student tuition. Facilities and administrative (F&A) costs will be provided in addition to direct costs. KY INBRE funding will terminate as of the start-date of an independent NIH research grant award.

If you plan to use human subjects, you must submit evidence of Human Subjects Education Certification.

SF 424 (R&R) FACE PAGE: 

Item 10 – CFDA number : leave blank; for TITLE: enter  "KY INBRE Pilot Project Award" 

Note: Maximum Budget $50,000 (travel costs limited to $2500 per year)


Letters of SupportInclude a letter verifying institutional support (e.g., release time, matching funds, etc.), and a support letter from the identified mentor/ collaborator. As noted previously, it is expected that the collaborator/mentor will also be willing to provide input into the NIH proposal development process. In the case of the use of a core research facility, include a letter from the administrator of the facility indicating availability and agreement with the conditions stated in the research plan and budget. Finally, a statement from an NIH program officer indicating your research topic is potentially fundable by NIH.

Review Considerations

KY INBRE applications are reviewed by scientific review groups administered by the KY INBRE Developmental Research Project Program and are evaluated for scientific and technical merit according to the NIH R15 or R16 review criteria as specified in the associated Funding Opportunity Announcement. It is critical that you carefully read and follow the directions of the R15 or R16 FOA. Incomplete applications will be returned without review.

Award Criteria

Funding for KY INBRE grants is limited and grants are awarded on a competitive basis. Funding decisions on individual applications will be based on the proposed research project's scientific merit, its relevance to NIH programs, and the likelihood that support of the project will ultimately result in a successful NIH R15 or R16 grant application. For renewal applications, research progress from previous KY INBRE funding, including publications and R15/R16 submissions and reviews, will be a significant factor in determining funding priority.

Progress Reports

Annual progress reports will be due to the KY INBRE office no later than Jan 15th

Copies of all submitted NIH proposals and reviews must be submitted to the KY INBRE office in a timely manner.


The completed application should be sent via email as a single PDF file to Dr. Bruce Mattingly, KY INBRE Program Coordinator. 

KY INBRE Application Checklist

Required Letter of Intent by announced due date.


Required at proposal due date:


Recommended proposal preparation steps:

Page updated Oct 10, 2023