ARC24 Tentative Agenda: Friday, March 1

9:30 am: Faculty Research Talk #1 Speaker TBA
Title TBA

9:45 am: Faculty Research Talk #2 Speaker TBA
Title TBA

10 am: Faculty Research Talk #3 Speaker TBA
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10:15 am: Faculty Research Talk #4 Speaker TBA
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10:30 am: Faculty Research Talk #5 Speaker TBA
Title TBA

11 am: Introduction 

11:05 am: Student Flash Talk #1 Speaker TBA
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11:10 am: Student Flash Talk #2 Speaker TBA
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11:15 am: Student Flash Talk #3 Speaker TBA
Title TBA

11:20 am: Student Flash Talk #4 Speaker TBA
Title TBA

11:25 am: Student Flash Talk #5 Speaker TBA
Title TBA

11:30 am: Student Flash Talk #6 Speaker TBA
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11:35 am: Student Flash Talk #7 Speaker TBA
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11:40 am: Student Flash Talk #8 Speaker TBA
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11:45 am: Student Flash Talk #9 Speaker TBA
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11:50 am: Student Flash Talk #10 Speaker TBA
Title TBA

• Student Workshops. Location TBA.

• Data Science Program/Workshop. Location TBA.

  • Bioinformatics Core Director: Dr. Eric Rouchka

  • PADS Hub (Applied Statistics) Core Director: Dr. Katie Thompson

• Electron Microscopy and Imaging Workshops (i.e. hands-on demonstrations). Location TBA.

  • EM Core Director and Associate Directors: 

    • Dr. Julia Aebersold (UofL)

    • Dr. John Balk (UK)

    • Dr. John Andersland (WKU)

• Comparative Genomic Resources of the UCSC Genome Browser. Location TBA.

Presented by Robert Kuhn from Robert Kuhn Consulting, LLC
The Comparative Genomics data on the UCSC Genome Browser are built in a series of steps that begin with the one-to-one alignment of individual genomes against a target genome. In the case of the human hg38 100-species vertebrate alignment, for example, each species is aligned to human. The raw alignments are linked together into Chains, representing segments in the same order and orientation on the two respective genomes. These are filtered into Nets to pull out the most likely long-range alignments that represent the underlying structure of the last common ancestor between the two species and to eliminate duplication of alignment due to repeats. Orthologs and paralogs can be distinguished at this point, providing insight into evolutionary events. The Nets from each of the species are then displayed together in the Conservation track, showing all 100 species aligned to human.  The display very nicely shows concepts including evolutionary distance and conservation and selection of exons over introns. This presentation will investigate this process in some detail.  Participants are encouraged to bring their own laptops.